Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. It does not only lead to somatic discomfort, but also adversely affect the health of humans in mental, psychological, physical, and many other aspects, thus directly reducing the quality of human life. Pain is one of the most common clinical symptoms, and has been recognized as a worldwide healthcare problem. However, at the current stage, the diagnosis and treatment of pain heavily rely on the subjective and inaccurate report of pain from patients. Since an objective and reliable measurement of pain is highly needed in various basic and clinical applications, several neuroimaging techniques have been adopted to reveal neurologic signature of pain perception and to predict pain based on nociceptive-evoked brain responses. This is becoming one of the worldwide hot topics of pain research.
To understand the basic mechanism of pain and analgesia, our research team aims to achieve the following research goals.
First, we aims to expand the basic knowledge of brain process of nociceptive inputs, thereby providing the foundation for an objective, quantitative and precise nociceptive-specific biomarker.
Second, based on the explored nociceptive-specific biomarker, we aims to provide an objective and reliable assessment of pain perception by developing effective pain prediction models and advanced pattern recognition algorithms.
Third, we aims to develop an effective bio-feedback system based on the pain measurement to relieve pain from patients by incorporating effective psycho-physiological training. This system, serves as an auxiliary means of analgesia, would provide a novel pain eliminating solution without any side effect for chronic pain patients, and help physicians to develop personalized and optimized analgesic solutions.
With the achievement of the above research goals, we will develop novel systems to measure pain and to eliminate pain from patients, thus helping to improve people's physical and mental health and improve the quality of people's life.